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Furthermore, in bile ductcannulated (BDC) rats, the average recovery rates of total radioactivity in bile, urine, feces, and cage cleaning fluid collected during 72 h after dosing were 9.08% 0.86%, 17.77% 6.35%, 2.73% 0.40%, and 0.91% 0.13%, respectively (Table 8

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1-6 Based on receptor availability at the tissues, estradiol is converted to estrone and further converted to estriol through the 16-alpha-hydroxyestrone metabolism pathway during Phase I metabolism

Fer-1 operates as a ferroptosis inhibitor, predominantly through the scavenging of lipid peroxides